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Aldactone Information
Common Aldatone indications
The retention of water in human body is a symptom of many health disorders. Sometimes it helps doctors diagnosing their patients; sometimes it makes the process of treatment more complicated. This way or another, water retention is a very serious symptom and it needs immediate treatment! Getting rid of extra water is favorable for patients' heart and blood pressure; that is why doctors often recommend a safe and effective water pill (diuretic) going under the name of Aldactone.
Aldactone is traditionally indicated in coping with:
- Primary hyperaldosteronism - establishing the diagnosis; short-term preoperative treatment of patients with primary hyperaldosteronism. Aldactone is good as long-term maintenance therapy for patients with discrete aldosterone-producing adrenal adenomas and patients with bilateral micro or macronodular adrenal hyperplasia (idiopathic hyperaldosteronism).
- Edematous conditions like congestive heart failure (management of edema and sodium retention); cirrhosis of the liver accompanied by edema and/or ascites (Aldactone is combined with bed rest and the restriction of fluid and sodium); the nephrotic syndrome (with restriction of fluid and sodium intake where other diuretics do not work).
- Essential hypertension when patients cannot be treated adequately with other agents or for whom other agents are considered inappropriate.
- Hypokalemia when other measures are considered inappropriate or inadequate.
- Severe heart failure (to increase survival, and to reduce the need for hospitalization).
Pregnancy - it is not advisable to prescribe Aldosterone without utter necessity exposing mother and fetus to unnecessary hazard. The drug does not prevent development of toxemia of pregnancy. Aldactone is indicated in pregnancy when edema is due to pathologic causes that get worse during pregnancy. If edema produces discomfort and cannot be relieved by rest, a short course of diuretics may provide relief and may be appropriate.
Aldactone forms and doses
Aldactone is available as oral tablets containing 25 mg, 50 mg, or 100 mg of the Aldosterone antagonist spironolactone. Inactive ingredients of each tablet include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide. Make sure you are not allergic to all those ingredients before taking Aldactone!
Aldactone dosage depends on the health disorder treated. Primary hyperaldosteronism -Aldactone is administered at a daily dosage of 400 mg for three to four weeks (long test) or for four days (short test) to diagnose the problem. After the diagnosis of hyperaldosteronism has been established, Aldactone is administered in doses of 100 to 400 mg daily in preparation for surgery. If patients cannot undergo surgery, Aldactone is used for long-term maintenance therapy at the lowest effective dosage determined for each patient individually.
Edema adults with congestive heart failure, hepatic cirrhosis or nephrotic syndrome are usually prescribed an initial daily dosage of 100 mg of Aldactone. As a rule the drug is administered in either single or divided doses ranging from 25 to 200 mg daily. If Aldactone is chosen to be the sole agent for diuresis, patients should take it for at least five days at the initial dosage level. If after five days an adequate diuretic response to Aldactone has not occurred, a second diuretic is prescribed. In such cases the dosage of Aldactone should remain unchanged.
Essential hypertension requires the initial daily dosage of 50 to 100 mg of Aldactone administered in either single or divided doses. Treatment with Aldactone should be continued for at least two weeks to achieve the maximum response.
Hypokalemia requires Aldactone dosage ranging from 25 mg to 100 mg daily. The medication is perfect when oral potassium supplements or other potassium-sparing regimens are considered inappropriate.
Severe heart failure - the treatment is started with Aldactone 25 mg taken once daily. Patients who tolerate 25 mg taken once daily may have their dosage increased to 50 mg once daily. Patients who do not tolerate 25 mg taken once-daily dose may have their dosage reduced to 25 mg of Aldactone every other day.
Warning! Aldactone overdose is a serious medical condition. Acute overdosage of Aldactone is characterized by drowsiness, mental confusion, maculopapular or erythematous rash, nausea, vomiting, dizziness, or diarrhea. Cases of hyponatremia, hyperkalemia, or hepatic coma in patients with severe liver disease have been reported, too. Hyperkalemia is possible in patients with impaired renal function. Induce vomiting as soon as possible and call the ambulance to get immediate medical help!
Aldactone typical side effects
Study possible Aldactone adverse reactions listed in order of decreasing severity:
- Digestive: Gastric bleeding, ulceration, gastritis, diarrhea and cramping, nausea, vomiting.
- Endocrine: gynecomastia, inability to achieve or maintain erection, irregular menses or amenorrhea, postmenopausal bleeding.
- Hematologic: agranulocytosis.
- Hypersensitivity: fever, urticaria, maculopapular or erythematous cutaneous eruptions, anaphylactic reactions, vasculitis.
- Metabolism: Hyperkalemia.
- Nervous system /psychiatric: mental confusion, ataxia, headache, drowsiness, lethargy.
- Liver / biliary: cases of mixed cholestatic/hepatocellular toxicity.
- Renal: Renal dysfunction including renal failure.
If you suspect you develop any of these, let your doctor know about it as soon as possible!
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