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Baclofen Information
General Baclofen detail and indications
Different medical emergencies require effective and reliable drugs to help patients cope with spasms. These days Baclofen is one of the most favorite muscle relaxants and antispastic drugs available as tablets for oral administration because. It is swiftly and extensively absorbed and eliminated in human body bringing relief within a few hours.
It is impossible to say how Baclofen works. It is known to inhibits both monosynaptic and polysynaptic reflexes at the spinal level. Although Baclofen can be considered an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no real evidence that actions Baclofen clinical efficiency depends on GABA system involvement.
Baclofen is usually prescribed to diminish the symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus and muscular rigidity. Baclofen can be of great use in patients with spinal cord injuries and other spinal cord diseases.
Nevertheless, it is useless to prescribe Baclofen if patients' spasticity is not a reversible one, that is why Baclofen is not recommended to treat skeletal muscle spasm resulting from rheumatic disorders. Baclofen is an object of medical speculations regarding its efficacy in stroke, cerebral palsy and Parkinson's disease, that is why it is never prescribed as basic medication.
Baclofen is available as 10 mg tablets - oval, white, scored in bottles containing 100 pills or in boxes containing 10 strips of 10 pills each. Higher doses of Baclofen are available as 20 mg capsules in bottles containing 100 pills or in boxes containing 10 strips of 10 pills each.
Please, keep your Baclofen away from children and domestic animals. Do not store the drug above 30ºC (86ºF) to preserve its medical properties.
Baclofen recommended doses and schedules
Baclofen intake is a very simple procedure - you should take it once a day at approximately the same time with a glass of water. Please, remember that the results of your treatment depend on the regularity of Baclofen intake, so try not to miss your doses and keep to the schedule recommended by your doctor.
Usual therapeutic dose of Baclofen in adult patients is 40-80 mg of Baclofen taken once daily orally. Nevertheless, your personal dose can be smaller because your doctor into account every detail of your current state and health record and calculates the safest dose for you. Make sure you never adjust the amount of medication taken without your doctor's consent.
Experienced doctors use titration to calculate your Baclofen dose:
- 5 mg t.i.d. for 3 days
- 10 mg t.i.d. for 3 days
- 15 mg t.i.d. for 3 days
- 20 mg t.i.d. for 3 days
As soon as the symptoms disappear, you keep to the lowest effective dose of possible. If Baclofen is not effective at all, patients should be slowly withdrawn from the drug.
Warning! The total daily dose of Baclofen should never exceed a maximum of 80 mg daily! Remember that Baclofen overdose is very dangerous! If you or someone taking Baclofen have vomiting, muscular hypotonia, drowsiness, accommodation disorders, coma, respiratory depression, and seizures, you have to empty the stomach promptly by inducing emesis and call 911 at once to save a human life!
Baclofen common side effects
Baclofen is a well-tolerated drug in the majority of patients. Nevertheless, you should be aware of Baclofen adverse reactions. Please, remember that any signs of allergic reaction to Baclofen is a very serious reason to seek immediate medical help!
The majority of other symptoms are bothersome but not dangerous. The most common adverse reactions of Baclofen is transient drowsiness (10%-63%), dizziness (5%-15%), weakness (5%-15%) and fatigue (2%-4%) that do not require medical attention.
Other possible side effects of Baclofen can affect the following systmes:
- Neuropsychiatric: confusion (1%-11%), headache (4%-8%), insomnia (2%-7%); and, rarely, euphoria, excitement, depression, hallucinations, paresthesia, muscle pain, tinnitus, slurred speech, coordination disorder, tremor, rigidity, dystonia, ataxia, blurred vision, nystagmus, strabismus, miosis, mydriasis, diplopia, dysarthria, epileptic seizure.
- Cardiovascular: hypotension (0%-9%). Rare instances of dyspnea, palpitation, chest pain, syncope.
- Gastrointestinal: nausea (4%-12%), constipation (2%-6%); and, rarely, dry mouth, anorexia, taste disorder, abdominal pain, vomiting, diarrhea, and positive test for occult blood in stool.
- Genitourinary: urinary frequency (2%-6%); and, rarely, enuresis, urinary retention, dysuria, impotence, inability to ejaculate, nocturia, hematuria.
- Other: rash, pruritus, ankle edema, excessive perspiration, weight gain, nasal congestion.
The higher is your dose of Baclofen, the bigger is the possibility of developing one or some side effects of the drug. If any side effects persists, call you doctor to find out what should be done next.
Baclofen warnings
- Baclofen is not recommended to pregnant and lactating women and pediatric patients under 12 years of age.
- Baclofen combined with acetaminophen, aspirin, caffeine and sodium oxybate can cause dangerous renal dysfunction.
- Baclofen is not the best choice for patients with kidney and liver problems.
- Baclofen intake makes people more dependant on alcohol, drugs and CNS depressants.
Baclofen causes drowsiness and slows down reflexes - be careful driving and performing any hazardous activities.
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