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Carbamazepine Information
The main reasons to indicate Carbamazepine
Numerous brain and NCS disorders can destroy normal human life and involve a person into a whirl of pain and misery. To help patients of this kind modern medicine offers them powerful anticonvulsants able of controlling their seizures and pain.
Carbamazepine belongs to anticonvulsant drugs, too. It proved to be effective in overcoming pain and seizures springing from epilepsy, trigeminal neuralgia, diabetic neuropathy and bipolar disorder. It works by blocking corresponding signals in human brain.
Carbamazepine is meant for long-term treatment. You will see the first stable results within 4 weeks from the first Carbamazepine intake. Pay attention to the following points to make sure your Carbamazepine therapy is safe and stable.
Carbamazepine contraindications
It is dangerous and even fatal using Carbamazepine if the patient:
- is pregnant or lactating;
- has a history of previous bone marrow depression;
- is hypersensitive to Carbamazepine (bad allergic reactions as possible);
- is sensitive to any of the tricyclic compounds, such as amitriptyline, desipramine, imipramine, protriptyline, nortriptyline;
- is taking monoamine oxidase (MAO) inhibitors - the interval between MAO and Carbamazepine is at least 14 days;
- is taking Nefazodone on a regular basis;
- has a liver or kidney disease; porphyria; heart disease or heart block; lupus; a history of mental illness; or glaucoma.
Tell your doctor about any health trouble and medical conditions you have or used to have before starting Carbamazepine therapy!
Carbamazepine food and drug interactions
Please, inform you doctor about any medication you take before starting Carbamazepine, because the drug is known to have many dangerous interactions. For instance, patients can pass an orange rubbery precipitate in their stool the day after ingesting Carbamazepine suspension immediately followed by Thorazine.
Cold or allergy medicine, narcotic pain killers, sleeping pills, muscle relaxers, other seizure medicines, and medicine for depression or anxiety can add to sleepiness caused by Carbamazepine.
Do not take alcohol while following Carbamazepine therapy - it can force the sedation.
Carbamazepine typical doses
Take your Carbamazepine with meals 2-4 times a day as indicated by your doctor. Do not srush or chew the tablets to avoid massive release of the medication. If you miss a dose, skip it and continue taking Carbamazepine according to your normal schedule.
Epilepsy in adult and pediatric patients over 12 years of age requires the starting dose of either 200 mg for tablets and XR tablets, or 1 teaspoon for suspension (400 mg/day). In case of necessity increase Carbamazepine at weekly intervals by adding up to 200 mg/day until the optimal response is obtained. In any case Carbamazepine dosage should not exceed 1000 mg daily in children 12-15 years of age, and 1200 mg daily in patients above 15 years of age. Maintenance: take the minimum effective dosage of 800-1200 mg taken daily.
Epilepsy in children 6-12 years of age: either 100 mg for tablets or Carbamazepine XR tablets, or 1/2 teaspoon for suspension (200 mg/day). Increase at weekly intervals by adding up to 100 mg/day until the best response is obtained. Carbamazepine dosage should never exceed 1000 mg daily. Try to adjust dosage to the minimum effective level, usually 400-800 mg taken daily.
Epilepsy in children under 6 years of age: 10-20 mg/kg/day of Carbamazepine taken daily. Increase the drug weekly to achieve optimal clinical responses. Maintenance: daily doses below 35 mg/kg.
Trigeminal Neuralgia: on the first day, take either 100 mg for tablets or Carbamazepine XR tablets, or 1/2 teaspoon for suspension, for a total daily dose of 200 mg. This daily dose may be increased by up to 200 mg/day using increments of 100 mg every 12 hours for tablets or XR tablets, or 50 mg (1/2 teaspoon) for suspension, to achieve the best painkilling effect. Do not exceed the dosage of Carbamazepine 1200 mg daily. Maintenance: 400-800 mg taken daily.
Attention! Every 3 months of the treatment reduce the Carbamazepine dose and try to discontinue the drug altogether.
Carbamazepine possible side effects
Tell your doctor if you have new or worsening depression or suicidal thoughts during the first several months of treatment, or whenever your dose is changed. Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.
Patients of Asian ancestry have a higher risk of developing serious skin reaction to Carbamazepine. Have some tests done before you start the medication to determine your risk of this skin reaction.
Carbamazepine may impair your thinking or reactions. Be careful if you drive, operate machinery or do anything that requires you to be awake and alert.
Avoid exposure to sunlight or artificial UV rays because Carbamazepine makes your skin more sensitive to sunlight and sunburn.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat!
Other serious Carbamazepine side effects are:
- fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
- pale skin, easy bruising or bleeding, unusual weakness;
- white patches or sores inside your mouth or on your lips;
- feeling short of breath, swelling of your ankles or feet;
- nausea, stomach pain, loss of appetite, jaundice (yellowing of the skin or eyes); or
- urinating less than usual.
They require immediate medical attention to make sure your life is out of danger.
Less serious Carbamazepine side effects include:
- feeling dizzy, drowsy, or unsteady;
- vomiting, diarrhea, constipation, stomach pain;
- confusion, headache, blurred vision;
- ringing in your ears;
- dry mouth, swollen tongue; or
- joint or muscle pain, leg cramps.
They tend to disappear in the course of time without causing any harm.
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