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Generic Estrace (Estradiol) Information
Generic Estrace (Estradiol) typical indications
Fair sex is blessed with the possibility of giving birth to children and this ability makes them strong. Nevertheless when female hormonal system is out of order it can be the cause of many serious health disorders. For instance, estrogen, a female sex hormone produced by the ovaries, is vital for female health and many normal processes in the body become impossible if a woman does not have enough estrogen. Estradiol is a semi-synthetic form of estrogen used to replace natural estrogens in female bodies. It is normally used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other recommendations include prevention of osteoporosis in postmenopausal women. Estradiol is sometimes used as part of powerful cancer treatment in women and men. In some cases Estradiol may be recommended for other purposes not mentioned in this medication guide.
Generic Estrace (Estradiol) normal doses and schedules
As the majority of sex hormones, Estradiol is taken once a day. The best way to get the most of your treatment is to take Estradiol regularly. The more doses you miss, the weaker is the effect of your treatment. Estradiol can be taken with or without food with some water. If you GI system is too sensitive, you should take your drug after a substantial meal.
The lowest Estradiol dose and regimen that will control symptoms are prescribed for treatment of moderate to severe vasomotor symptoms, vulval and vaginal atrophy associated with the menopause. The medication should be discontinued as promptly as possible. The usual Estradiol dosage is from 1 to 2 mg taken daily. The minimal effective dose for maintenance therapy should be determined by titration. Remember to take Estradion in a cyclic way - 3 weeks on and 1 week off.
The lowest Estradiol dose and regimen are also the best for treatment of female hypoestrogenism due to hypogonadism, castration, or primary ovarian failure. Only 1 to 2 mg of Estradion should be taken daily to control presenting symptoms. The minimal effective dose for maintenance therapy should be determined by titration, too.
A considerably higher amount of Estradion is required for treatment of breast cancer in appropriately selected women and men with metastatic disease: 10 mg of the drug should be taken three times daily for a period of at least three months.
Low Estradion doses are also effective for treatment of advanced androgen-dependent carcinoma of the prostate the suggested dosage is 1 to 2 mg of the drug taken three times daily. The benefit of the therapy can be judged by symptomatic improvement of the patient.
Careful dose calculation is needed for prevention of osteoporosis. What is more, Estradion is recommended only if all non-estrogen medications proved to be useless.
Generic Estrace (Estradiol) reported side effects
It is important to underline that Estradiol is very effective and the majority of patients experience considerable relieve of symptoms within a few days. Nevertheless, Estradiol is a hormonal drug having numerous side effects some of which are rather severe.
Warning! Any allergic reaction to Estradiol such as hives; difficulty breathing; swelling of your face, lips, tongue, or throat require immediate medical help!
1. Genitourinary system side effects are numerous and can be dangerous. Patients reported about:
- Changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flow; breakthrough bleeding, spotting, dysmenorrhea;
- Increase in size of uterine leiomyomata;
- Vaginitis, including vaginal candidiasis;
- Change in amount of cervical secretion;
- Changes in cervical ectropion;
- Ovarian cancer; endometrial hyperplasia; endometrial cancer.
2. Breasts reactions include:
- tenderness, enlargement, pain;
- nipple discharge, galactorrhea;
- fibrocystic breast changes;
- breast cancer.
3. Cardiovascular adverse reactions are:
- deep and superficial venous thrombosis;
- pulmonary embolism;
- thrombophlebitis;
- myocardial infarction;
- stroke; increase in blood pressure.
4. Gastrointestinal side effects often are as follows:
- Nausea, vomiting;
- Abdominal cramps, bloating;
- Cholestatic jaundice;
- Increased incidence of gallbladder disease; Pancreatitis;
- Enlargement of hepatic hemangiomas.
5. Skin reactions include:
- Chloasma or melasma that may persist when drug is discontinued;
- Erythema multiforme, Erythema nodosum;
- Hemorrhagic eruption;
- Loss of scalp hair;
- Hirsutism;
- Pruritus, rash
6. Eyes adverse reactions:
- Retinal vascular thrombosis;
- Steepening of corneal curvature;
- Intolerance to contact lenses.
7. Central Nervous System side effects:
- Headache, migraine, dizziness;
- Mental depression;
- Chorea;
- Nervousness, mood disturbances, irritability;
- Exacerbation of epilepsy;
- Dementia
8. Miscellaneous side effects reported during Estradiol therapy:
- Increase or decrease in weight;
- Reduced carbohydrate tolerance;
- Aggravation of porphyria;
- Edema;
- Arthralgias; leg cramps;
- Changes in libido;
- Urticaria;
- Angioedema;
- Anaphylactoid/anaphylactic reactions;
- Hypocalcemia;
- Exacerbation of asthma;
- Increased triglycerides.
If you develop any of the abovementioned side effects or experience any unusual bothersome sensations, do not hesitate to call 911 and ask about the best ways to behave in your situation.
Generic Estrace (Estradiol) warnings
It is forbidden to take Estradiol if you are pregnant or lactating.
Try to give up smoking before Estradiol therapy; this is the best way to prevent serious health disorders including blood clots.
Inform your doctor about any other health disorder you have and drugs you take to make your Estradiol treatment absolutely safe.
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