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Generic Tegretol (Carbamazepine) Information
Generic Tegretol (Carbamazepine) general indications
Severe brain and CNS disorders often require swift and powerful medications to handle the critical situation. Carbamazepine is an anticonvulsant formulated to guarantee rapid patients' relieve. The drug if effective in easing pain and seizures springing from epilepsy, trigeminal neuralgia, diabetic neuropathy and bipolar disorder.
Unfortunately, Carbamazepine is not a simple medication for your body. Read the following information to find out if it is a suitable treatment for you.
Generic Tegretol (Carbamazepine) contraindications and warnings
You should not take Carbamazepine to avoid major health risks if you:
- are pregnant or lactating;
- have a history of previous bone marrow depression;
- are hypersensitive to the drug;
- are sensitive to any of the tricyclic compounds, such as amitriptyline, desipramine, imipramine, protriptyline, nortriptyline;
- are taking monoamine oxidase (MAO) inhibitors - discontinue them 14 days before starting Carbamazepine;
- are taking Nefazodone;
- have a history of liver or kidney disease; porphyria; heart disease or heart block; lupus; a history of mental illness; or glaucoma.
Generic Tegretol (Carbamazepine) doses and intake
Carbamazepine should be taken as prescribed by your healthcare provider and prevent severe health troubles. Carbamazepine should be taken regularly with meals 2-4 times a day for at least 4 weeks. As a rule, Carbamazepine doses are close to those mentioned below.
Epilepsy in adult and pediatric patients over 12 years of age: start with either 200 mg for tablets and XR tablets, or 1 teaspoon for suspension (400 mg/day). Increase Carbamazepine at weekly intervals by adding up to 200 mg/day until the optimal response is obtained. Warning! Carbamazepine dosage should not exceed 1000 mg daily in children 12-15 years of age, and 1200 mg daily in patients above 15 years of age. Maintenance: take the minimum effective dosage of 800-1200 mg taken daily.
Epilepsy in children 6-12 years of age: either 100 mg for tablets or Carbamazepine XR tablets, or 1/2 teaspoon for suspension (200 mg/day). Increase at weekly intervals by adding up to 100 mg/day until the optimal response is obtained. Carbamazepine dosage generally should never exceed 1000 mg daily. Try to adjust dosage to the minimum effective level, usually 400-800 mg taken daily.
Epilepsy in children under 6 years of age: 10-20 mg/kg/day as Carbamazepine tablets, or as suspension. Increase the drug weekly to achieve optimal clinical responses. Maintenance: daily doses below 35 mg/kg.
Trigeminal Neuralgia: on the first day, take either 100 mg for tablets or Carbamazepine XR tablets, or 1/2 teaspoon for suspension, for a total daily dose of 200 mg. This daily dose may be increased by up to 200 mg/day using increments of 100 mg every 12 hours for tablets or XR tablets, or 50 mg (1/2 teaspoon) for suspension, to achieve painkilling effect. Do not exceed the dosage of Carbamazepine 1200 mg daily. Maintenance: 400-800 mg taken daily.
Attention! Once every 3 months of the treatment period try to reduce the Carbamazepine dose and discontinue the drug.
Generic Tegretol (Carbamazepine) reported side effects
Attention! Physicians must be aware that abrupt discontinuation of any anticonvulsant drug including Carbamazepine may lead to seizures or even status epilepticus with its life-threatening hazards!
The usual mild Carbamazepine adverse reactions, particularly during the initial phases of therapy, are dizziness, drowsiness, unsteadiness, nausea, and vomiting. To minimize the possibility of such reactions, take the low dosage therapy.
The majority of severe adverse reactions have been observed in the hemopoietic system and skin, the liver, and the cardiovascular system.
Hemopoietic System: Aplastic anemia, agranulocytosis, pancytopenia, bone marrow depression, thrombocytopenia, leukopenia, leukocytosis, eosinophilia, anemia, acute intermittent porphyria, variegate porphyria, porphyria cutanea tarda.
Skin: Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS), pruritic and erythematous rashes, urticaria, photosensitivity reactions, alterations in skin pigmentation, exfoliative dermatitis, erythema multiforme and nodosum, purpura, aggravation of disseminated lupus erythematosus, alopecia, and diaphoresis. In certain cases, discontinuation of therapy may be necessary.
Cardiovascular System: Congestive heart failure, edema, aggravation of hypertension, hypotension, syncope and collapse, aggravation of coronary artery disease, arrhythmias and AV block, thrombophlebitis, thromboembolism (e.g., pulmonary embolism), and adenopathy or lymphadenopathy. Some of these cardiovascular complications have resulted in fatalities.
Liver: Abnormalities in liver function tests, cholestatic and hepatocellular jaundice, hepatitis; very rare cases of hepatic failure.
Pancreatic: Pancreatitis.
Respiratory System: Pulmonary hypersensitivity characterized by fever, dyspnea, pneumonitis, or pneumonia.
Genitourinary System: urinary frequency, acute urinary retention, oliguria with elevated blood pressure, azotemia, renal failure, and impotence. Albuminuria, glycosuria, elevated BUN, and microscopic deposits in the urine have also been reported. There have been very rare reports of impaired male fertility and/or abnormal spermatogenesis.
Nervous System: Dizziness, drowsiness, disturbances of coordination, confusion, headache, fatigue, blurred vision, visual hallucinations, transient diplopia, oculomotor disturbances, nystagmus, speech disturbances, abnormal involuntary movements, peripheral neuritis and paresthesias, depression with agitation, talkativeness, tinnitus, hyperacusis, neuroleptic malignant syndrome.
Digestive System: Nausea, vomiting, gastric distress and abdominal pain, diarrhea, constipation, anorexia, and dryness of the mouth and pharynx, including glossitis and stomatitis.
Eyes: Scattered punctate cortical lens opacities, increased intraocular pressure as well as conjunctivitis, have been reported. Although a direct causal relationship has not been established, many phenothiazines and related drugs have been shown to cause eye changes.
Musculoskeletal System: Aching joints and muscles, and leg cramps.
Metabolism: Fever and chills. Inappropriate antidiuretic hormone (ADH) secretion syndrome has been reported in cases of tap water intoxication, with decreased serum sodium (hyponatremia) and confusion. Decreased levels of plasma calcium leading to osteoporosis have been reported.
Other: Multiorgan hypersensitivity reactions occurring days to weeks or months after initiating treatment have been reported in rare cases. Signs or symptoms may include, but are not limited to fever, skin rashes, vasculitis, lymphadenopathy, disorders mimicking lymphoma, arthralgia, leukopenia, eosinophilia, hepatosplenomegaly and abnormal liver function tests. These signs and symptoms may occur in various combinations and not necessarily concurrently. Signs and symptoms may initially be mild. Various organs, including but not limited to, liver, skin, immune system, lungs, kidneys, pancreas, myocardium, and colon may be affected.
Isolated cases of a lupus erythematosus-like syndrome have been reported. There have been occasional reports of elevated levels of cholesterol, HDL cholesterol, and triglycerides in patients taking anticonvulsants. A case of aseptic meningitis, accompanied by myoclonus and peripheral eosinophilia, has been reported in a patient taking carbamazepine in combination with other medications.
Follow your doctor's recommendations to avoid painful Carbamazepine side effects and get the most of your treatment!
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